Sickle cellrelated pain crises are the primary cause of health care encounters in patients with sickle cell disease.1 These crises result in a decrease in quality of life2 and an increase in the risk of death.3 Crises … Eligible participants were insulin-naive patients … Leave a Reply. This trial assesses the efficacy and safety of semaglutide, a GLP-1RA, as an add-on to basal insulin. The effects of gender, age and baseline CV risk on outcomes are important considerations for further study. Diabetes Obes Metab. Change from baseline (week 0) in body weight was evaluated after 30 weeks of treatment. Sustain (Agrotain) has been independently trialled by AFBI on both grassland and tillage. SUSTAIN-6 was initiated in February 2013 as a preapproval trial aimed at enhancing the probability that regulatory guidance was met in the development program. a SUSTAIN 7 included 0.5 mg and 1.0 mg doses for Ozempic ® and 0.75 mg and 1.5 mg doses for Trulicity ®. You have reached the maximum number of saved studies (100). Women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period. 2018 Oct;20(10):2426-2434. doi: 10.1111/dom.13396. The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 3 trial is a phase 3a comparative study that evaluated the efficacy, safety, and tolerability of once-weekly semaglutide 1.0 mg s.c. versus that of once-weekly exenatide ER 2.0 mg s.c. over 56 weeks in adults with type 2 diabetes who are inadequately controlled on oral antidiabetic drugs (OADs). At the visits participants will have blood taken and eye tests done. Semaglutide s.c. Once-Weekly in Type 2 Diabetes: A Population Pharmacokinetic Analysis. 2017 Apr;5(4):251-260. doi: 10.1016/S2213-8587(17)30013-X. Participants will inject semaglutide under the skin once a week. Talk with your doctor and family members or friends about deciding to join a study. One malignant neoplasm (basal cell carcinoma) was reported in the study in a patient treated with semaglutide 1.0 mg. Stable daily dose(s) for 90 days prior to the day of screening of: Any metformin formulations (equal to or above1500 mg or maximum tolerated or effective dose) alone or in combination with sulfonylureas (SU) (equal to or above half of the maximum approved dose according to local label or maximum tolerated or effective dose), Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within the past 90 days prior to the day of screening. However, prior to the SUSTAIN 10 clinical trial, a Europe-based head-to-head comparison of the two drugs had not been conducted. • PlayStation®4: NA and EU megaservers for maintenance – February 24, 6:00AM EST (11:00 UTC) - 9:00AM EST (14:00 UTC) Magicka Warden Sustain in Trial Content . An exception is short-term treatment (no longer than 7 days in total) with insulin in connection with inter-current illness - History of chronic or idiopathic acute pancreatitis - Screening calcitonin value above or equal to 50 ng/L (pg/mL) - Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) - Impaired renal function defined as eGFR (estimated glomerular filtration rate ) below 30 mL/min/1.73 m^2 per modification of diet in renal disease (MDRD) formula (4 variable version) - Acute coronary or cerebrovascular event within 90 days before randomisation - Heart failure, New York Heart Association class IV. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials. An analysis of DR AEs in SUSTAIN 1–5 and the Japanese trials showed no evidence of increased DR AEs with semaglutide vs placebo or active comparators . • PlayStation®4: NA and EU megaservers for maintenance – February 24, 6:00AM EST (11:00 UTC) - 9:00AM EST (14:00 UTC) Magicka Warden Sustain in Trial Content . In this next article in this Moving Points in Nephrology feature on quality improvement, we provide health care professionals with strategies to sustain … Sickle cell disease is characterized by the presence of sickle hemoglobin (HbS), chronic hemolysis, recurrent pain episodes (called sickle cellrelated pain crises or vaso-occlusive crises), multiorgan dysfunction, and early death. Go. pii: dgz072. ESO_Nightingale Stahlor wrote: » ESO_Nightingale wrote: » something needs to be done about the absurd effect of health stacking in pvp. Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials. Once weekly, administrated subcutaneously (s.c. under the skin). Attention ... Feb 10, 2016 Free Download Adobe LiveCycle Designer ES4 11.0.0.20130303.1. Individual Participant Data (IPD) Sharing Statement: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com. For general information, Learn About Clinical Studies. Nuendo 11 Trial. 2019 Oct;45(5):409-418. doi: 10.1016/j.diabet.2018.12.001. doi: 10.1210/jc.2018-02685. Prev 1 2 Next. SUSTAIN-6 was a randomised, double-blind, placebo-controlled, parallel-group trial … Diabetes Ther. 2019 Oct;45(5):409-418. doi: 10.1016/j.diabet.2018.12.001. Methods. Choosing to participate in a study is an important personal decision. The SUSTAIN 6 trial demonstrated that once-weekly semaglutide (0.5 and 1.0 mg) significantly reduced major adverse cardiovascular (CV) events (MACE) vs placebo in subjects with … 2020 Feb 1;105(2). This was a double-blind, parallel-group, phase 3b, randomised controlled trial done at 111 centres in 11 countries. GREATER COMBINED REDUCTIONS IN HbA(1C) ≥1.0% AND WEIGHT ≥5.0% WITH SEMAGLUTIDE VERSUS COMPARATORS IN TYPE 2 DIABETES. Serial Number Adobe Livecycle Designer Es4 Rating: 4,7/5 6958reviews. United Kingdom: Adequate contraceptive measures are defined as established use of oral, injected or implanted hormonal methods of contraception, placement of an intrauterine device or intrauterine system, barrier methods of contraception (condom or occlusive cap with spermicidal foam/gel/film/cream/suppository), male sterilisation (where partner is sole partner of subject), or true abstinence (when in line with preferred and usual lifestyle) - Any chronic disorder or severe disease which, in the opinion of the investigator, might jeopardise subject's safety or compliance with the protocol - Treatment with any glucose lowering agent(s) in a period of 90 days prior to screening. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02054897. Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials… U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Agrotain reduces volatilisation, ensuring the Nitrogen is available to fuel crop growth all season long. The SUSTAIN 10 trial was the first Europe-based head-to-head trial to compare s.c. OW semaglutide vs s.c. OD liraglutide, and had relatively broad inclusion criteria in terms of the range of background medications and baseline characteristics. From week 13 to week 40, the 1.0 mg group will receive an additional injection of semaglutide placebo in order to maintain the blinding. Sustain definition, to support, hold, or bear up from below; bear the weight of, as a structure. Aroda VR, Ahmann A, Cariou B, Chow F, Davies MJ, Jódar E, Mehta R, Woo V, Lingvay I. Livecycle Es4 Trial Serial 11 > DOWNLOAD. Epub 2018 Aug 23. The design of the SUSTAIN 7 trial has been previously reported.36 Briefly, this was an open-label trial in which subjects with uncontrolled T2D were randomised to receive semaglutide OW 0.5 mg … Listing a study does not mean it has been evaluated by the U.S. Federal Government. Type 2 diabetes (T2D) is a complex disorder that requires individualized treatment strategies. extended half-life. Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial. Bear is the only competitively viable trial ultimate and … Rodbard HW, Bellary S, Hramiak I, Seino Y, Silver R, Damgaard LH, Nayak G, Zacho J, Aroda VR. Why Should I Register and Submit Results? Buy Sustain XL All Natural.Energy Stamina & Extra-Strength Booster Trial Pack (4) ... $17.06 ($4.27 / Count) $16.11 ($4.03 / Count) First delivery on Mar 2 First delivery on Mar 1 Ships from: Amazon. Missing data were imputed from a mixed model for repeated measurements with treatment and country as fixed factors and baseline value as covariate, all nested within visit. Participants will keep taking their pre-study diabetes tablets throughout the study. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03989232. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. Female participants who can get pregnant will be checked 11 … Sorli C, Harashima SI, Tsoukas GM, Unger J, Karsbøl JD, Hansen T, Bain SC. Semaglutide injected subcutaneously (s.c., under the skin) once-weekly. Regulatory guidance specifies the need to establish the cardiovascular safety of new therapies for type 2 diabetes in order to rule out excess cardiovascular risk.5 The preapproval Trial to Evaluate Cardiovascular and O… Women cannot take part if pregnant, breast-feeding or planning to become pregnant during the study period. The SUSTAIN 8 trial – reported in The Lancet Diabetes & Endocrinology – demonstrated a significantly greater reduction in HbA1c levels with semaglutide versus the sodium-glucose … 2020 Jan 1;105(1):. Methods: We did a randomised, open-label, non-inferiority, parallel-group, multicentre, multinational, phase 3a trial (SUSTAIN 4) at 196 sites in 14 countries. SUSTAIN 10 is, thus, both representative of patients that physicians are likely to consider for treatment with a GLP-1RA and reflective of … 2018 Aug;9(4):1533-1547. doi: 10.1007/s13300-018-0458-5. Aims: SUSTAIN 10 compared the efficacy and safety of the anticipated most frequent semaglutide dose (1.0mg) with the current most frequently prescribed liraglutide dose in Europe (1.2mg), reflecting clinical practice. The median duration of exposure was 21.6 months in SUSTAIN … Urea is treated with a stabiliser called Agrotain. Distraction 11 Distraction Using Paddle Distractors, Trials or Scrapers 12 5. OZEMPIC is a drug that improves blood sugar control in adults with type 2 diabetes mellitus (DM) when used in addition to diet and exercise. However, short term insulin treatment for a maximum of 14 days prior to the day of screening is allowed, as is prior insulin treatment for gestational diabetes, Renal impairment measured as estimated glomerular filtration rate (eGFR) value of <30 mL/min/1.73 m^2 according to Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) creatinine equation as defined by KDIGO 2012 classification, Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Novo Nordisk’s SUSTAIN 9 trial was conducted in Asia, Europe and North America. SUSTAIN 6 was time‐ and event‐driven (≥104 weeks’ exposure and ≥122 primary outcome events), 32 whereas PIONEER 6 was solely event‐driven (≥122 primary outcome events). January 20, 2021. The study will last for about 49 weeks. once-weekly subcutaneous administration due to its .  (Clinical Trial), Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes, Placebo Comparator: Semaglutide placebo 1.0 mg, Placebo Comparator: Semaglutide placebo 0.5 mg, 18 Years and older   (Adult, Older Adult), Birmingham, Alabama, United States, 35216, Hawaiian Gardens, California, United States, 90716, Los Angeles, California, United States, 90057, Montclair, California, United States, 91763, Northridge, California, United States, 91324, Colorado Springs, Colorado, United States, 80920, Boynton Beach, Florida, United States, 33472, Jacksonville, Florida, United States, 32277, Miami Lakes, Florida, United States, 33016, Pembroke Pines, Florida, United States, 33026, Brownsburg, Indiana, United States, 46112, Lexington, Kentucky, United States, 40504, Olive Branch, Mississippi, United States, 38654, Belvidere, New Jersey, United States, 07823, Albuquerque, New Mexico, United States, 87102, Charlotte, North Carolina, United States, 28277, Whiteville, North Carolina, United States, 28472, Levittown, Pennsylvania, United States, 19056, Spartanburg, South Carolina, United States, 29303, Vancouver, British Columbia, Canada, V6J 1S3, Saint-Petersburg, Russian Federation, 194358, Saint-Petesburg, Russian Federation, 195257, Port Elizabeth, Eastern Cape, South Africa, 6014, Bloemfontein, Free State, South Africa, 9301, Johannesburg, Gauteng, South Africa, 1818, Johannesburg, Gauteng, South Africa, 1827, Durban, KwaZulu-Natal, South Africa, 4450, Umkomaas, KwaZulu-Natal, South Africa, 4170, Change in HbA1c (Glycosylated Haemoglobin) [ Time Frame: Week 0, week 30 ], Change in Body Weight [ Time Frame: Week 0, week 30 ], Change in Fasting Plasma Glucose (FPG) [ Time Frame: Week 0, week 30 ], Change in Systolic and Diastolic Blood Pressure [ Time Frame: Week 0, week 30 ], Subjects Who Achieve (Yes/no):HbA1c Below 7.0% (53 mmol/Mol) American Diabetes Association Target [ Time Frame: At 30 weeks of treatment ], Subjects Who Achieve (Yes/no):HbA1c Below or Equal to 6.5% (48 mmol/Mol) American Association of Clinical Endocrinologists Target [ Time Frame: At 30 weeks of treatment ]. The trial … To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) clinical trial program for semaglutide comprises 6 pivotal global phase 3a trials (SUSTAIN 1 through 6) and 2 Japanese phase 3a trials. SUSTAIN-6 trial design. Female participants who can get pregnant will be checked 11 times for pregnancy via urine tests. At the visits participants will have blood taken and eye tests done. b Results apply to Ozempic ® plus standard of care vs standard of care alone in SUSTAIN 6 trial… CV safety trials conducted to meet the FDA guidance generally use an efficient trial … 17 Magnetic resonance imaging FLAIR-diffusion mismatch excluded two thirds in the WAKE-UP trial. Cubase 11 Trial December 16, 2020 We have just released the trial versions of Cubase Pro 11 and Cubase Elements 11 in order for you to try out the new features before making the final decision to purchase the version that meets your demands best. For general information, Learn About Clinical Studies. Results for all trials based on a sensitivity analysis of retrieved dropout population. Percentage of subjects who achieve (yes/no): HbA1c below 7.0% (53 mmol/mol) American Diabetes Association target after 30 weeks' treatment. The SUSTAIN trial also showed that increases in alanine aminotransferase (ALT) reported in previous trials were infrequent and transient with no new increases observed beyond week 12 of the 24-week trial. However, most organizational change is not maintained. Please remove one or more studies before adding more. 2018 Sep;20(9):2210-2219. doi: 10.1111/dom.13353. The peptide backbone of semaglu- tide is similar to that of liraglutide and, like liraglutide, has a 94% homology with native GLP-1. Percentage of subjects who achieve (yes/no): HbA1c below 6.5% (48 mmol/mol) American Diabetes Association target after 30 weeks' treatment. Epub 2018 Jun 15. Participants will get a dose of either 1.0 mg or 2.0 mg semaglutide once a week - which dose is decided by chance. Diabetes Obes Metab. Sold … Semaglutide placebo injected once-weekly from week 13 to week 40. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Inclusion Criteria: - For Japan only: Male or female, age above or equal to 20 years at the time of signing inform consent - Subjects diagnosed with type 2 diabetes and treated with diet and exercise for at least 30 days before screening - HbA1c 7.0 - 10.0 % (53 - 86 mmol/mol) (both inclusive) Exclusion Criteria: - Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive method (adequate contraceptive measures as required by local regulation or practice) throughout the trial including the 5 week follow-up period. Ahrén B, Atkin SL, Charpentier G, Warren ML, Wilding JPH, Birch S, Holst AG, Leiter LA. You have reached the maximum number of saved studies (100). In both the CVOTs, trial completion rate was high (SUSTAIN 6: 97.6%; PIONEER 6: 99.7%) with vital status at end-of-trial known for 99.6% of patients in SUSTAIN 6 and 100% in PIONEER 6. Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials. We did a double-blind, randomised, parallel-group, international, placebo-controlled phase 3a trial (SUSTAIN 1) at 72 sites in Canada, Italy, Japan, Mexico, Russia, South Africa, UK, and USA (including hospitals, clinical research units, and private offices). Carlsson Petri KC, Ingwersen SH, Flint A, Zacho J, Overgaard RV. Change from baseline (week 0) in HbA1c was evaluated after 30 weeks of treatment. Epub 2018 Jul 9. J Clin Endocrinol Metab. THE primary prosecution witness, Mr. Michael Wetkas, in the Code of Conduct Tribunal (CCT) trial of the Senate President, Dr. Bukola Saraki, may have created another major pothole for the federal government’s prosecution team, as he has stated on cross-examination that there was insufficient evidence to sustain Count 11 of the 16 paragraph indictment against the Senate President. Exposure-response analysis for evaluation of semaglutide dose levels in type 2 diabetes. [Epub ahead of print] Erratum in: J Clin Endocrinol Metab. Capehorn M, Ghani Y, Hindsberger C, Johansen P, Jódar E. Once-Weekly Semaglutide Reduces HbA(1c) and Body Weight in Patients with Type 2 Diabetes Regardless of Background Common OAD: a Subgroup Analysis from SUSTAIN 2-4 and 10. Reductions in insulin resistance are mediated primarily via weight loss in subjects with type 2 diabetes on semaglutide. Results from the completed trials support the superiority of semaglutide for reduction of … Subjects were grouped according to gender, age (50–65 … Epub 2020 Feb 5. Diabetes Obes Metab. 11 … Eligible participants were insulin-naive patients with type 2 diabetes, aged 18 years and older, who had insufficient glycaemic control with metformin either alone or in combination with a sulfonylurea. Epub 2019 Mar 13. Although increasing the basal insulin dose and/or adding mealtime insulin is often effective, this approach can increase the risk of hypoglycemia and lead to weight gain in an often overweight population (6). c At Week 40 for SUSTAIN 7, at Week 30 for SUSTAIN 4 and 5. Epub 2018 Jun 15. The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) 3 trial is a phase 3a comparative study that evaluated the efficacy, safety, and tolerability of once-weekly semaglutide 1.0 … SUSTAIN-6 was part of the global phase 3a trial programme for semaglutide, which included six sepa-rate clinical trials of over 7000 patients. Eligible patients were aged 18 years or older and had type 2 diabetes with … Warren M, Chaykin L, Trachtenbarg D, Nayak G, Wijayasinghe N, Cariou B. Semaglutide as a therapeutic option for elderly patients with type 2 diabetes: Pooled analysis of the SUSTAIN 1-5 trials. Try now <- Back to: Detailview. SUSTAIN was a multicenter, multinational, randomized, placebo-controlled, double-blind, 12-month clinical trial (NCT01895361) that evaluated the safety and efficacy of crizanlizumab … Participants will have 9 clinic visits and 2 phone calls with the study doctor. The trial results show that SustaiN yields are consistently as good as CAN, […] Semaglutide, a GLP-1 analogue with an extended half-life of approximately 1 week (which permits once-weekly subcutaneous administration),4 is currently in development but not yet approved for the treatment of type 2 diabetes. ET, in the U.S. Senate at the Capitol in Washington, D.C. Shares of Moderna Inc. MRNA, +1.69% gained 11.3% in premarket trading on Monday after the company said it started to dose participants in the Phase 3 trial … See more. To achieve sustainable change, quality improvement initiatives must become the new way of working rather than something added on to routine clinical care. Go. SustaiN is protected urea Nitrogen fertiliser. The median duration of exposure was 21.6 months in SUSTAIN 6 and 15.9 months in PIONEER 6. Prev 1 2 Next. DeVries JH, Desouza C, Bellary S, Unger J, Hansen OKH, Zacho J, Woo V. Achieving glycaemic control without weight gain, hypoglycaemia, or gastrointestinal adverse events in type 2 diabetes in the SUSTAIN clinical trial programme. Epub 2020 Mar 19. In the SUSTAIN-6 CV outcome trial, Tina Vilsbøll, MD, DMSc, clinical manager at Steno Diabetes Center in Copenhagen, Denmark, and colleagues randomly assigned 3,297 adults with type 2 … Missing data were imputed from a mixed model for repeated measurements with treatment and country as fixed factors and baseline value as covariate, all nested within visit. Key Results. Read our, ClinicalTrials.gov Identifier: NCT03989232, Interventional Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trials. Overgaard RV, Lindberg SØ, Thielke D. Impact on HbA1c and body weight of switching from other GLP-1 receptor agonists to semaglutide: A model-based approach. Missing data were imputed from a mixed model for repeated measurements with treatment and country as fixed factors and baseline value as covariate, all nested within visit. Change from baseline (week 0) in systolic and diastolic blood pressure was evaluated after 30 weeks of treatment. Event Start Time: Feb. 11, 2021 11:50 AM EST Event End Time: Feb. 11, 2021 8:00 PM EST Leave a Reply. Change from baseline (week 0) in FPG was evaluated after 30 weeks of treatment. Trial design. 2020 Mar;22(3):442-451. doi: 10.1111/dom.13955. Study record managers: refer to the Data Element Definitions if submitting registration or results information. All participants will receive one injection per week during a 12-week dose escalation period. Studies a U.S. FDA-regulated Drug Product: Studies a U.S. FDA-regulated Device Product: Change in HbA1c [ Time Frame: From baseline (week 0) to week 40 ], Change in body weight (kg) [ Time Frame: From baseline (week 0) to week 40 ], Change in fasting plasma glucose (FPG) [ Time Frame: From baseline (week 0) to week 40 ], Change in body mass index (BMI) [ Time Frame: From baseline (week 0) to week 40 ], Change in waist circumference [ Time Frame: From baseline (week 0) to week 40 ], HbA1c below 7% [ Time Frame: At week 40 ], HbA1c equal to or below 6.5% [ Time Frame: At week 40 ], Weight loss equal to or above 5% [ Time Frame: At week 40 ], Weight loss equal to or above 10% [ Time Frame: At week 40 ], Number of treatment emergent severe or blood glucose confirmed symptomatic hypoglycaemic episodes [ Time Frame: From first dose (week 0) to week 40 ], Change in pulse rate [ Time Frame: From baseline (week 0) to week 40 ], Male or female, age equal to or above18 years at the time of signing informed consent, Diagnosed with T2D at least 180 days prior to the day of screening, HbA1c of 8-10% (64-86 mmol/mol) (both inclusive). THE primary prosecution witness, Mr. Michael Wetkas, in the Code of Conduct Tribunal (CCT) trial of the Senate President, Dr. Bukola Saraki, may have created another major pothole for the federal government’s prosecution team, as he has stated on cross-examination that there was insufficient evidence to sustain Count 11 of the 16 paragraph indictment against the Senate President. The aim of this trial is to investigate efficacy and safety of semaglutide once-weekly versus placebo in drug-naïve subjects with type 2 diabetes. DeSouza C, Cariou B, Garg S, Lausvig N, Navarria A, Fonseca V. Efficacy and Safety of Semaglutide for Type 2 Diabetes by Race and Ethnicity: A Post Hoc Analysis of the SUSTAIN Trials. I think one of the main issues when it comes to trials isn't actually sustain, but rather damage and how much of it is spread into bear. SUSTAIN 10 compared the efficacy and safety of semaglutide 1.0 mg … 2020-11-17T14:24:44Z. Novo Nordisk’s SUSTAIN 9 trial was conducted in Asia, Europe and North America. 2019 Jun;25(6):589-597. doi: 10.4158/EP-2018-0444. ETD=estimated treatment difference. See more.  (Clinical Trial), Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor), Sponsor staff involved in the clinical trial is masked according to company standard procedures, Efficacy and Safety of Semaglutide 2.0 mg s.c. Once-weekly Compared to Semaglutide 1.0 mg s.c. Once-weekly in Subjects With Type 2 Diabetes, 18 Years and older   (Adult, Older Adult), Birmingham, Alabama, United States, 35205, Buena Park, California, United States, 90620, Los Angeles, California, United States, 90057, San Diego, California, United States, 92103, Spring Valley, California, United States, 91978, Van Nuys, California, United States, 91405, Walnut Creek, California, United States, 94598, Colorado Springs, Colorado, United States, 80906, Coral Gables, Florida, United States, 33134, Jacksonville, Florida, United States, 32216, Adairsville, Georgia, United States, 30103, Gillespie, Illinois, United States, 62033, Lexington, Kentucky, United States, 40503, Louisville, Kentucky, United States, 40213, Lake Charles, Louisiana, United States, 70601, Sterling Heights, Michigan, United States, 48310-3503, Jefferson City, Missouri, United States, 65109, Trenton, New Jersey, United States, 08611, New Windsor, New York, United States, 12553, Chapel Hill, North Carolina, United States, 27517, Greensboro, North Carolina, United States, 27408, Salisbury, North Carolina, United States, 28144, Statesville, North Carolina, United States, 28625, Wilmington, North Carolina, United States, 28401, Corvallis, Oregon, United States, 97330-3737, Gaffney, South Carolina, United States, 29341, Greenville, South Carolina, United States, 29615, Chattanooga, Tennessee, United States, 37404, Kingsport, Tennessee, United States, 37660, Memphis, Tennessee, United States, 38119-4806, Shavano Park, Texas, United States, 78231, Olympia, Washington, United States, 98502, Walla Walla, Washington, United States, 99362-4445, Wenatchee, Washington, United States, 98801-2028, Mount Pearl, Newfoundland and Labrador, Canada, A1N 1W7, Clinical Reporting Anchor and Disclosure (1452).
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